Volume 5, issue 4
Schizofrenia
A neurodevelopmental animal model of schizophrenia
BARBARA K. LIPSKA1, DANIEL R. WEINBERGER1
1. Clinical Brain Disorders Branch, IRP, NIMH, Neuroscience Center at St. Elizabeths
Postępy Psychiatrii i Neurologii, 1996, 5, 369-373
Keywords: schizophrenia, pathogenesis, animal model, neurodevelopmental concept
Abstract
An interesting model is presented, simulating characteristics of human behavior and the course of schizophrenia in man in an experiment on rats. Many assumptions of the so-called neurodevelopmental concept of the pathogenesis of schizophrenia are verified in the model, by means of destruction of limbic structures in early stages of fetal life. (Eds.)
Address for correspondence:
Dr Barbara Lipska, Clinical Brain Disorders Branch, IRP, NIMH, Neuroscience Center at
St. Elizabeths, Washington DC 20032, USA