2000 issue 2

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Volume 9, issue 2

Original article

Lack of association between polymorphisms of DRD2 and DRD3 genes and schizophrenia

JOANNA HAUSER1, PIOTR M. CZERSKI1, MALWINA CZARNY-RATAJCZAK3, PAWEŁ KAPELSKI1, SEBASTIAN GODLEWSKI1, FILIP RYBAKOWSKI2, MONIKA DMITRZAK4, Anna Leszczyńska1, ANNA LATOS-BIELEŃSKA3, JANUSZ K. RYBAKOWSKI1
1. Klinika Psychiatrii Dorosłych Akademii Medycznej w Poznaniu
2. Kliniki Psychiatrii Dzieci i Młodzieży Akademii Medycznej w Poznaniu
3. Katedry i Zakładu Genetyki Medycznej Akademii Medycznej w Poznaniu
4. Uniwersytetu im. A. Mickiewicza w Poznaniu (studentka)
Postępy Psychiatrii i Neurologii, 2000, 9, 149-157
Keywords: schizophrenia, genetics, DRD2, DRD3

Abstract

Contribution of genetic factors toetiopathogenesis of schizophrenia is well documented.Susceptibility to the disease is probably due toan epistatic interaction ofmany genes. This associationstudy was conducted to investigatefrequenciesof alleles and genotypes of the so-called candidategenes in a group of patients with schizophrenia(n=129), and in healthy controls (n=111). Thepaper presents results of association studies on polymorphisms of candidate genes: DRD2 (T/G substitutionin intron 6, at the position -72 from the 5' endof exon 7, and C/T substitution in codon 313 in exon7) and DRD3 (Ball polymorphism in codon 9 of thefirst exon) in schizophrenia. No relationship betweenthe polymorphisms under study and schizophreniahas been confirmed.

Address for correspondence:
Prof Joanna Hauser, Klinika Psychiatrii Dorosłych Akademii Medycznej,
ul. Szpitalna 27/31, 60-572 Poznań