2002 issue 2

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Volume 11, issue 2

Review papers

Huntington’s chorea as an exemplification of the role of genetic aspects in neurodegenerative diseases

KRZYSZTOF NADGRODKIEWICZ1, IRENA KIFER1
1. Oddział Neurologii Wojewódzkiego Szpitala Specjalistycznego w Radomiu
Postępy Psychiatrii i Neurologii, 2002, 11, 149-153
Keywords: Huntington’s disease, dynamic mutations, huntingtin
Abstract

The nature of dynamic mutations, their presumable underlying mechanism, as well as their role in the pathogenesis of Huntington's disease are presented in the paper. Amplification of selected trinucleotide sequences, the anticipation phenomenon, and genome imprinting theory are discussed in more detail.

Address for correspondence:
Adres: Dr KrzysztofNadgrodkiewicz, Oddział Neurologii Wojewódzkiego Szpitala Specjalistycznego,
ul. Aleksandrowicza 5, 26-617 Radom