2002 issue 3

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Volume 11, issue 3

Dementias

Fronto-temporal dementia

Piotr Wierzbiński2, Tadeusz Pietras1
1. Pracownia Gerontologii Kliniki Pneumonologii i Alergologii Akademii Medycznej w Łodzi
2. Studenckie Koło Naukowego przy Klinice Pneumonologii i Alergologii Akademii Medycznej w Łodzi
Postępy Psychiatrii i Neurologii, 2002, 11, 247-257
Keywords: fronto-temporal dementia, tau protein
Abstract

A number of distinct clinical syndromes have been described that are associated with both frontal and temporal lobes and have non Alzheimer pathology. The nosological status of fronto-temporal dementia has been a matter of controversy, in view of the clinical manifestations and distribution of the nature of histopathological change. Fronto-temporal dementias include fronto-temporal dementia, progressive nonfluent aphasia, semantic dementia, and lobar degeneration and motor neuron disease. There are two morphological forms: Pick's disease and dementia tacking neuropathology. Although most fronto-temporal dementias are sporadic, familial fronto-temporal dementia linked to chromosome 17 q21-22, which is characterized by prominent filamentous tau inclusion, is caused by multiple tau gene mutation. Filamentous deposits made of tau protein are typical for the most of fronto-temporal dementia's clinical and morphological forms.

Address for correspondence:
Adres: Dr Tadeusz Pietras, Pracownia Gerontologii Kliniki Pneumonologii i Alergologii
Akademii Medycznej, ul. Kopcińskiego 22, 90-153 Łódź, te!. (42) 6787505,fax: (42) 6782129