2008 issue 3

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Volume 17, issue 3

Review article

Matrix metalloproteinases in gliomas

Anna Łapka1, Jagoda Drąg1, Anna Goździalska1, Jerzy Jaśkiewicz1
1. Zakład Analityki Biochemicznej, Wydział Farmaceutyczny z Oddziałem Analityki Medycznej Collegium Medicum Uniwersytetu Jagiellońskiego w Krakowie
Postępy Psychiatrii i Neurologii 2008; 17 (3): 207-211
Keywords: matrix metalloproteinases (MMPs), extracellular matrix (ECM), gliomas

Abstract

Objectives. Gliomas, tumors derived from glial cells, represent about 50% of all cerebral tumors. The aim of this review is to outline the role of matrix metalloproteinases in the pathological mechanism underlying the development of gliomas.
Review. Matrix metalloproteinases (MMPs) are a group of proteolytic enzymes that modify the tissue structure andfunction under various physiological and pathological conditions. MMPs activity in the nervous tissue was observed to increase in the process of cancerogenesis. In this type of tissue extracellular matrix (ECM) is produced mainly by glial cell secretion. Pathological ECM changes usually result from glial cells' function impairment due to the carcinogenic process, leading eventually to glioma development. Substrate specificity of MMPs in the CNS was demonstrated, as well as a positive correlation between MMPs activity and cancer progression. MMP-2, MMP-9 and MMP-14 were evidenced to be the main proteolytic enzymes in the brain tissue ECM under pathological conditions. Moreover, collagen proteins type I, II, III, IV, V, laminin, fibronectin, aggrecan, perlecan and tenascin were found to be the main substrates for those enzymes.
Conclusions. Understanding the MMPs function in glioma progression will allow to enlarge the present body of knowledge about this cancer group. In the future MMPs may also serve as a potential prognostic marker.

Address for correspondence:
Anna Łapka
Zakład Analityki Biochemicznej, Wydział Farmaceutyczny z Oddziałem Analityki Medycznej
Uniwersytet Jagielloński Collegium Medicum
ul. Medyczna 9, 30-688 Kraków
e-mail: alapka@cm-uj.krakow.pl
tel: 012 657 39 64