Objectives. The etiology of impulsivity and aggressive behavior is explained in terms of many factors, including social, environmental, and socioeconomic characteristics. Moreover, neurobiological factors seem to be of the utmost importance. The concurrence of affective disorders with the individual's enhanced impulsivity significantly increases his/her suicide risk.
Review. The findings of recent years have shown the endocannabinoid system involvement in a number of processes occurring in the central nervous system. Interaction between the endocannabinoid system, neurotransmitters and the neuroendocrine system suggests a considerable influence of endocannabinoids on psychological well-being.
Conclusions. Endocannabinoid receptor antagonists reduce aggression, impulsivity and may lead to mood improvement, thus potentially contributing to a decrease in suicide rates.