2008 issue 3


Volume 17, issue 3

Original article

Usefulness of diffusion-weighted magnetic resonance imaging (DWI-MR) with apparent diffusion coefficient (ADC) mapping for detection of fresh foci of demyelination and ADC changes in the cerebral white matter in patients with sclerosis multiplex

Renata Poniatowska1, Małgorzata Lusawa1, Jarosław Krakiewicz1, Wanda Sobczyk2, Grzegorz Witkowski2
1. Zakład Neuroradiologii Instytutu Psychiatrii i Neurologii w Warszawie
2. I Klinika Neurologii Instytutu Psychiatrii i Neurologii w Warszawie
Postępy Psychiatrii i Neurologii 2008; 17 (3): 201-205
Keywords: DWI-MR, multiple sclerosis, ADC, NAWM


Objectives. The purpose of the study was to evaluate the usefulness of diffusion-weighted magnetic resonance imaging (DWI-MR) in patients with multiple sclerosis (MS).
Method. The MR examination including standard MR imaging and diffusion-weighted images (DWIs) was performed in 66 patients diagnosed with MS and in 23 controls.
MS patients were divided into two groups on the grounds of their MRI scans: one consisted of patients showing plaque formation, and the other of those without any demyelination symptoms. Apparent diffusion coefficients (ADCs) were measured in the normal-appearing white matter (NAWM) of frontal, parietal and temporal lobes of both cerebral hemispheres.
Results. Statistically significant differences in white matter ADCs were found between MS patients (M= 117.32; SD = 8.68; SE = 1.069) and the control group (M = 109.21; SD = 10.251; SE = 2.138)), as well as between MS patients with numerous foci of demyelination and those without such foci (M= 119.47; SD = 7.965; SE = 1.105, and M = 111.3; SD = 8.617; SE = 2.303, respectively).
Conclusions. ADC mapping is a simple and repeatable method allowing to assess the degree of white matter damage. The technique may be useful not only for the assessment of MS severity, but also for long-term monitoring of its course and of treatment outcomes.

Address for correspondence:
Dr Renata Poniatowska
Zakład Neuroradiologii Instytutu Psychiatrii i Neurologii
ul. Sobieskiego 9