2008 issue 4

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Volume 17, issue 4

Review article

Neuroimaging in schizophrenia - new techniques, new possibilities

Marta Gawłowska1,2, Jolanta Rabe-Jabłońska1,2, Piotr Gębski1,2
1. II Klinika Psychiatrii UM w Łodzi
2. Zakład Radiologii i Diagnostyki Obrazowej UM w Łodzi
Postępy Psychiatrii i Neurologii 2008; 17 (4): 357-363
Keywords: schizophrenia, white matter, neuroimaging, magnetic resonance, diffusion tensor imaging, magnetization transfer imaging
Abstract

Objectives. The aim of this study is to present the currently available methods of neuroimaging as well as the possibilities they open up in the diagnostics of schizophrenia, monitoring its course, and seeking potential causes of the disease.
Review. There are two predominant pathogenetic hypotheses for schizophrenia: neurodevelopmental, proposing that schizophrenia is caused by abnormal processes during the central nervous system maturation, and neurodegenerative, considering the illness to result from atrophic/degenerative processes within the CNS structures. schizofrenięizophrenia has been regarded so far mainly as a condition due to grey matter abnormalities, while white matter irregularities were supposed to be of minor importance.
Conclusions. A majority of research findings obtained with the most recent neuroimaging techniques confirm that the development of schizophrenia symptoms is caused by abnormalities in the course of the CNS maturation. More and more attention is devoted to white matter as the structure that might possibly have a crucial role in the pathogenesis of schizophrenia symptoms.

Address for correspondence:
II Klinika Psychiatrii w Łodzi
Ul. Czechosłowacka 8/10, 92-216 Łódź
e-mail: ADomagala@b1kpsa.am.lodz.pl