1994 issue 2

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Volume 3, issue 2

Farmakoterapia neurologiczna

Sclerosis multiplex – new possibilites of immunotherapy

Anna Członkowska1, KATARZYNA BIEGANOWSKA1
1. Klinika Chorób Naczyniowych Układu Nerwowego IPiN w Warszawie
Postępy Psychiatrii i Neurologii, 1994, 3, 156-163
Keywords: : sclerosis multiplex, immunotherapy

Abstract

Many years' clinical observations have indicated that the administration of non-specific global immunosupression has no satisfactory effect on the course of SM. Some more selective immunosuppresion methods are discussed in the paper. One of them seems to be clinically hopeful: a cellular vaccine, i.e. T receptor blocking by copolymer 1 and evoking tolerance by oral administration of base-protein of myelin. Less selective methods, such as application of antibodies against immunological reaction mediators (e.g. TNF), or antibodies against some subpopulations of cells are currently under study. The treatment with beta-interferone has stirred much interest in recent years. Research findings of a large multi-center study in the USA suggest that the preparation reduces the relapse rate and prevents the formation of new demyelinisation plaques in the brain. However, the findings require corroboration.

Address for correspondence:
Klinika Chorób Naczyniowych Układu Nerwowego IPiN w Warszawie