1996 issue 4

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Volume 5, issue 4

Schizofrenia

Infections with the Borna disease virus in persons with mental or neurological disorders

FILIP RYBAKOWSKI1
1. Akademii Medycznej w Poznaniu (student VI roku Wydziału Lekarskiego)
Postępy Psychiatrii i Neurologii, 1996, 6, 375-381
Keywords: Borna disease virus, mental disorders, neurological disorders

Abstract

The Borna disease virus is the cause of cerebral meningitis and encephalitis in sheep and horses. This fatal disease is endemic in the Central Europe region. The virus is characterized by a strong neurotropism and in this respect indicates a considerable affinity to the limbic system. Clinical symptoms of the infection as well as intensity of inflammatory reaction of the c.n.s. "depend on the response on the infected organism's immunological system. In recent years a hypothesis has been posed concerning a probable contribution of this factor to the pathogenesis of some mental and neurological disorders in man. A review of the state-of-the-art research literature on prevalence of infection with the Borna disease virus in affective disorders, schizophrenia, and in some neurological conditions is presented in the paper.

Address for correspondence:
Filip Rybakowski, ul. Limanowskiego 15A/2, 60-744 Poznań