1996 issue 4

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Volume 5, issue 4

Schizofrenia

Selected MRI parameters in schizophrenic patients: T2 relaxation time measurements

Marek Jarema1, MARZANNA CHOMA1, Renata Poniatowska2, RENATA KRAWCZYK2, PIOTR KOZŁOWSKI2
1. Krajowego Zespołu Konsultanta Medycznego w dziedzinie Psychiatrii
2. II Kliniki Psychiatrycznej IPiN w Warszawie
Postępy Psychiatrii i Neurologii, 1996, 5, 383-392
Keywords: schizophrenia, MRI

Abstract

In order to evaluate relationships between the clinical picture and neuroradiological pattern in schizophrenia MRI examination was performed in 70 patients. Cortical atrophy was found in 37% of the subjects. These patients were older, and hospitalized not only more often, but also for longer periods. Intensity of schizophrenic symptoms (including positive, negative and depressive ones) did not differentiate between patients with and without cortical atrophy. T2 relaxation time measurements revealed more numerous changes in the right cerebral hemisphere. T2 time values from the right frontal middle gyrus were significantly higher in patients with less marked schizophrenic symptoms. T2 time values from the grey matter of the frontal inferior gyrus in the right hemisphere were the higher the older were the patients, while T2 values from the corresponding area in the left hemisphere were the higher the later was the onset of schizophrenia. T2 time values from the amygdaloid nucleus were positively correlated with psychopathological symptoms intensity prior to treatment, positive symptoms intensity after treatment, clinical improvement after treatment, and with the breadth of the Sylvian fissure. Further research is needed to explain the significance of the parameters under study for clinical practice.

Address for correspondence:
Prof. Marek Jarema, 11/ Klinika Psychiatryczna IPiN, Al. Sobieskiego 1/9, 02-957 Warszawa