1996 suplement 1

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Volume 5, suplement 1

Original article

Dementia and the amygdaloid body

JERZY DZIEWIĄTKOWSKI1, JANUSZ MORYŚ1, BARBARA BILLEWICZ-BOBEK2, PRZEMYSŁAW KOWIAŃSKI1
1. Zakładu Anatomii i Neurobiologii AM w Gdańsku
2. Instytutu Radiologii i Radioterapii AM w Gdańsku
Postępy Psychiatrii i Neurologii, 1996, 5, suplement, 1 (3), 15-18
Keywords: amygdaloid body, Alzheimer's disease, morphometry

Abstract

In the terminal stage of Alzheimer's disease the average volume of the amygdaloid body is by about 56% smaller than that in control cases. The total number of neurons in the amygdaloid body amounts to about 4 million, while in patients with Alzheimer's disease it is decreased to about 1.2 million (by 70%). Even in the terminal stage of the disease degenerating processes in nerve cells are continuing – on the average 65% of neurons indicate neurofibrillary pathology, while in the control group only in about 2% of neurons neurofibrillary tangles are found. Due to both neuronal loss and marked neurofibrillary pathology in the terminal stage of the disease the total number of neurons showing no pathological alterations decreases to about 460 thousand. Such neurons are relatively the least numerous in the following structures: the cortical nucleus, the additional basal nucleus, and the transitory cortical-amygdaloid field.

Address for correspondence:
Dr Jerzy Dziewiątkowski, Zakład Anatomii i Neurobiologii AM, ul. Dębinki 1,80-211 Gdańsk.