1997 suplement 2

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Volume 6, suplement 2

Badania

Immunological changes in schizophrenia

ANNA SŁUŻEWSKA1, Janusz Rybakowski1, MAGDALENA SOBIESKA2
1. Kliniki Psychiatrii Dorosłych AM w Poznaniu
2. Pracowni Immunologii Komórkowej Zakładu Immunologii Klinicznej i Alergologii Instytutu Chorób Wewnętrznych w Poznaniu
Postępy Psychiatrii i Neurologii, 1997, 6, suplement 2 (5), 23-30
Keywords: schizophrenia, immunological system, acute phase proteins, interleukins

Abstract

In 35 schizophrenic patients with acute symptoms prior to pharmacotherapy and in 20 controls serum concentration of the following 5 acute phase proteins was estimated: C reactive protein (CRP), alpha-1-acid glycoprotein (AGP), alpha-1-antichymotrypsin (ACT), celluroplasmin (Cp), and haptoglobin (Hp), as well as concentrations of interleukin-6 (IL-6), soluble IL-6 receptor (sIL-6R), for interleukin-2 (sIL-2R), and interleukin-1 receptor antagonist (IL-1RA). In the patients under study as compared to the control group, concentrations of AGP, HP, IL-6, sIL-6R, sIL-2R and IL-1RA were found to be significantly higher. Schizophrenic patients had significantly lower values of the AGP glycosylation coefficient (AGP-RC). Obtained results indicate a chronic activation of the immunological system in patients suffering from schizophrenia.

Address for correspondence:
Dr Anna Służewska,
Klinika Psychiatrii Dorosłych AM,
ul. Szpitalna 27/33,
60-572 Poznań