1999 issue 1

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Volume 8, issue 1

Choroby infekcyjne o.u.n.

The Lyme disease (borreliosis) – a multisystem disease

TERESA HERMANOWSKA-SZPAKOWICZ1
1. Kliniki Chorób Pasożytniczych i Neuroinfekcji Akademii Medycznej w Białymstoku
Postępy Psychiatrii i Neurologii, 1999, 8, 15-25
Keywords: borreliosis, erythema migrans, neuroborreliosis, Lyme arthritis, Lyme carditis

Abstract

The paper presents the Lyme borreliosis–a disease induced by Gram-negative bacteriatreponemaBorreliaburgdorferi. The disease is moreand more often recognized in Poland due both toavailability of specific serologic methods and toa growing body of knowledge. The treponema reservoirin the natural environment includes rodents,domestic and wild animals, as well as birds, while thebacteria vector are tics of the Ixodes family. Aboveall, the disease affects foresters farmers and huntersas high-risk groups. In the pathogenesis ofborreliosisimmunomodulatory and immunostimulating role of the bacteria cell components should be taken intoaccount. This pertains especially to its surface antigensevoking cross-reactions will other bacteria. Twostages can be distinguished in the course of thedisease: (1) limited infection (an early form), and(2) disseminated infection (multiple erythema migrans,early neuroborreliosis, dermatitis, neurologicalsymptoms, arthralgia symptoms, and pathologicalchanges in other organs). Pathogenesis, clinical pictureand treatment of the disease are discussed, withan emphasis on efficacy of cephalosporins administeredin various forms of borreliosis. As regardsprevention, a preliminary evaluation is presented ofa vaccine introduced in the United States.

Address for correspondence:
Pro! Teresa Hermanowska-Szpakowicz, Klinika Chorób Pasożytniczych i Neuroinfekcji AM, ul. Żurawia 14, 15-540 Białystok