1999 issue 4


Volume 8, issue 4

Zaburzenia somatogenne

The role of polyunsaturated fatty acids peroxidation process in the pathogenesis of dementia syndromes

Tadeusz Pietras1
1. Kliniki Pneumonologii i Alergologii AM w Łodzi
Postępy Psychiatrii i Neurologii, 1999, 8, 419-430
Keywords: dementia, Alzheimer's disease, lipids peroxidation, reactive forms of oxygen


Alzheimer's disease is one of majorcauses of dementia syndromes. Many studies haveevidenced that in this disease the process of lipidsperoxidation in the central nervous system is enhanced.Reactive forms of oxygen produced in thepresence of amyloid protein induce the process of lipid peroxidation impairing nerve cells junction.The brain contains a large amount of polyunsaturated fatty acids, particularly susceptible to damageby free radicals with subsequent peroxidationof lipids. Alphatocopherol is a widely known antioxidantslowing down the process offatty acidsoxidation. The substance was found to restrainneurotoxicity of amyloid deposits and the c.n.s.damage caused by reactive forms of oxygen. Clinicalresearch has confirmed the protective role of tocopherol. The latter drug turned out to slowdown the progress of moderately advanced Alzheimer's disease.

Address for correspondence:
Dr Tadeusz Pietras, Klinika Pneumonologii i Alergologii AM,
ul. Kopcińskiego 22,90-153 Łódź