2000 issue 1


Volume 9, issue 1

Stwardnienie Rozsiane

Interferon treatment outcomes in patients with subacute sclerosing panencephalitis

Wanda Sobczyk1, Jerzy Kulczycki1, EWA PIŁKOWSKA1, BOŻENA IWIŃSKA-BUKSOWICZ1, TERESA JAKUBOWSKA1, Krystyna Niedzielska1
1. I Klinika Neurologiczna Instytutu Psychiatrii i Neurologii w Warszawie
Postępy Psychiatrii u Neurologii, 2000, 9, 45-53
Keywords: subacute sclerosing panencephalitis, treatment, interferons


This article discusses attempts to treat patients with subacute sclerosing panencephalitis with interferons. This method of treatment was applied over a span of about twenty years in one of three variants: (1) in seven patients natural interferon beta (Rentschler's Fiblaferon) was administered into the fluid space intralumbarly, (2) in seven patients naturalinterferon alpha (produced by the Institute of Hygiene in Helsinki) was administered intraventricularly by means of an epidurally implanted Rickham receptacle, and (3) in five patients recombined alpha 2b interferon was likewise administered intraventricularly by means of a Rickham receptacle. The best clinical outcomes were observed in group (2). No effects of the interferon treatment on immunological disorders were observed. Slight modifications of the bioelectrical activity of the brain were observed, however.

Address for correspondence:
Wanda Sobczyk, I Klinika Psychiatryczna Instytutu Psychiatrii i Neurologii,
Al. Sobieskiego 1/9,02-957 Warszawa