This study measured the three dimensions of sense of coherence (comprehensibility, manageability and meaningfulness) in patients with multiple sclerosis (sclerosis multiplex – SM) and compared the results with the results of neurologically, psychologically and physically healthy controls. Thirty patients with SM were given Antonovsky's SOC-29 and a personal inventory developed by Kossakowska to control for sex, duration of illness, activity and physical fitness. The healthy controls were also given the SOC-29 and controlled for sex, age and education. No significant differences in level of sense of coherence were found between the healthy subjects and the SM patients. However, sick women had higher comprehensibility scores than sick men and even healthy women and therefore sick men had significantly lower comprehensibility scores than healthy men and sick women. No significant differences in level of meaningfulness were found between the sick men and women on the one hand and healthy controls on the other. Sick women had higher manageability than sick men. Level of self-sufficiency and duration of illness did not contribute significantly to the variance of sense of coherence. On the other hand, patients who were occupationally or socially active or active in the family had higher sense of meaningfulness then non-active patients. These results suggest that special attention in the rehabilitation of SM patients should be given to enhancing sense of meaningfulness of patients' experiences, if only by encouraging patients to be more active occupationally, socially and in the family.