2001 issue 1


Volume 10, issue 1


An overview of candidate genes in affective disorders

Anna Leszczyńska1, PIOTR CZERSKI2
1. Klinika Psychiatrii Dorosłych Akademii Medycznej w Poznaniu
2. Pracowni Genetyki Psychiatrycznej Katedry Psychiatrii Akademii Medycznej w Poznaniu
Postępy Psychiatrii i Neurologii, 2001, 10, 33-43
Keywords: affective disorders, candidate genes, biochemica, concepts


Advances in the molecular genetics research into the etiology of affective disorders are outlined. Two approaches are used in the research: the candidate gene method and the whole genome screening. The paper presents findings of studies using the former approach, where the candidate gene (theoretically associated with the etiology of a given disorder) is selected. The studies refer mostly to biochemical concepts of affective disorders etiology. Reported findings of these studies indicate that in bipolar affective disorder a significant role is played by genes coding tyrosine hydroxylase, catechol-0-methyltransferase, monoamine oxidase type A and B, gamma-aminobutyric acid receptors and adenosine triphosphatase, while in unipolar affective disorder the D4 dopamine receptor coding gene may be of importance.

Address for correspondence:
Dr Anna Leszczyńska,
Klinika Psychiatrii Dorosłych Akademii Medycznej,
ul. Szpitalna 27/33,
60-572 Poznań