Three cases of cerebral stroke in the course of the antiphospholipid syndrome in systemic lupus erythematosus (SLE) are presented. In alt the three female patients SLE was diagnosed after the stroke, even though signs suggestive of a systemic disease had been present much earlier. In the first case the symptoms included glomerulonephritis and myocardial infarction, in the second one – thrombocytopenia (due to which splenectomy was performed) and myocardial infarction, while in the third case – arterial thrombosis of lower limbs, spontaneous abortions, recurring pneumonia, and leucopenia. A possibility of a systemic disease had been taken into account in alt the three cases, due to the patients' young age and past history. This was confirmed by laboratory tests results, especially by elevated anticardiolipin and antinuclear antibodies levels. In all the cases the course of SLE was severe. However, in two cases the administered treatment (with antibiotics, piracetam, prednisone, cyclophosphamide) resulted in an amelioration of symptoms of neurological deficit, while in one case the disease was fatal. Our cases evidence that alt stroke patients (especially young ones) should be thoroughly analyzed for systemic diseases involving the risk of cerebral stroke.