2001 issue 3

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Volume 10, issue 3

Review article

Metabotropic glutamate receptors: their physiological role and significance in CNS pathology

Piotr Maciejak2, DARIUSZ ROKICKI1, AGNIESZKA I. CZŁONKOWSKA1, MAREK SIEMIĄTKOWSKI2, Halina Sienkiewicz-Jarosz3, JANUSZ SZYNDLER1, Adam Płaźnik1,2
1. Katedry i Zakładu Farmakologii Doświadczalnej i Klinicznej Akademii Medycznej w Warszawie
2. Zakładu Farmakologii i Fizjologii Układu Nerwowego Instytutu Psychiatrii i Neurologii w Warszawie
3. I Klinika Neurologii Instytutu Psychiatrii i Neurologii w Warszawie
Postępy Psychiatrii i Neurologii, 2001, 10, 199-217
Keywords: metabotropic glutamate receptors, ionotropic glutamate receptors, excitatory amino acids

Abstract

The aim of this paper is to present the state of the art concerning the role of metabotropic glutamate receptors (mGluRs) in the CNS physiology and pathology. In the first part of this work a classification of mGluRs and their distribution in the CNS are outlined. The influence of mGluRs on the regulation of calcium and potassium channels as well as interaction of these receptors with other neurotransmitter systems are discussed. The second part of the article presents mGluRs involvement in CNS pathology and a potential role of the ligands of these receptors in the treatment of pain, epilepsy, neurodegenerative diseases, anxiety, depression and drug addictions

Address for correspondence:
Prof. Adam Płaźnik,
Zakład Farmakologii i Fizjologii Układu Nerwowego Instytutu Psychiatrii i Neurologii,
Al. Sobieskiego 9,
02-957 Warszawa,
e-mail: adaplaz@yahoo.com