Aim – The authors present most recent results of in vitro and in vivo studies concerning neuroprotective activity of EGb 761.
Review – Numerous studies have been carried out for many years in search for effective methods of prevention and therapy of neurodegenerative processes. Various groups of medicines (i.e. antioxidants, antagonists of glutamatergic receptors, neurotrophic factors, substances adjusting cellular metabolism, inhibitors of apoptosis, and immunosuppressive drugs) may act as neuroprotective agents sweeping away free radicals. EGb 761 activity has a number of underlying mechanisms, with a pivotal role of oxidative stress prevention. Moreover the drug ameliorates cellular metabolism, and inhibits both the process of apoptosis and beta-amyloid toxicity.
Conclusions – Preclinical trials indicate that EGb 761, a standardized Ginkgo biloba leaf extract, can inhibit the development of neurodegenerative processes.