Vascular dementia is due to brain lesions resulting from vascular dysfunction of various origin. The treatment of vascular dementia usually consists in amelioration of cerebral blood supply.
Aim – to assess clinical efficacy of vinpocetine in relation to its dosage in the treatment of vascular dementia.
Subjects – 58 vascular dementia patients aged 65.8 lat ± 8.7 years.
Method – Vascular dementia was diagnosed according to NINDS-AIREN criteria. Dementia severity was assessed pre – and post-treatment using the Mini Mental State Examination (MMSE) and Clinical Global Impression – CGI scales. Prior to treatment the mean MMSE score was 19.6, while CGI mean score was 3. 72. None of the patients received any long-term nootropic medication during that time. The mean duration of treatment was 189.1weeks.
Results – In patients receiving 30 mg of vinpocetine daily a statistically significant increase was found post-treatment: by 1.3 point on the MMSE and by 37 point on CGI. No significant change in the patients' state was noted in the group treated with 15 mg/daily – their dementia had not aggravated in the course of the follow-up period (i.e. over 3 years on the average). Conclusions – The findings confirm a neuroprotective effect of vinpocetine in vascular dementia. The dose of 15 mg/daily prevents deterioration of vascular dementia, while the dose of 30 mg/daily may result in an improvement of cognitive functions.