2003 issue 2

Back

Volume 12, issue 2

Original article

Relationship between vinpocetine dosage and its efficacy in vascular dementia

Krzysztof Małyszczak1, Jerzy Leszek1, ANDRZEJ KLEJNA1
1. Katedra i Klinika Psychiatrii Akademii Medycznej we Wrocławiu
Postępy Psychiatrii i Neurologii, 2003, 12 (2), 155-159
Keywords: vascular dementia, vinpocetine

Abstract

Vascular dementia is due to brain lesions resulting from vascular dysfunction of various origin. The treatment of vascular dementia usually consists in amelioration of cerebral blood supply.

Aim – to assess clinical efficacy of vinpocetine in relation to its dosage in the treatment of vascular dementia.

Subjects – 58 vascular dementia patients aged 65.8 lat ± 8.7 years.

Method – Vascular dementia was diagnosed according to NINDS-AIREN criteria. Dementia severity was assessed pre – and post-treatment using the Mini Mental State Examination (MMSE) and Clinical Global Impression – CGI scales. Prior to treatment the mean MMSE score was 19.6, while CGI mean score was 3. 72. None of the patients received any long-term nootropic medication during that time. The mean duration of treatment was 189.1weeks.

Results – In patients receiving 30 mg of vinpocetine daily a statistically significant increase was found post-treatment: by 1.3 point on the MMSE and by 37 point on CGI. No significant change in the patients' state was noted in the group treated with 15 mg/daily – their dementia had not aggravated in the course of the follow-up period (i.e. over 3 years on the average). Conclusions – The findings confirm a neuroprotective effect of vinpocetine in vascular dementia. The dose of 15 mg/daily prevents deterioration of vascular dementia, while the dose of 30 mg/daily may result in an improvement of cognitive functions.

Address for correspondence:
Dr Krzysztof Malyszczak, Klinika i Katedra Psychiatrii Akademii Medycznej,
ul. J. Kraszewskiego 25, 50-229 Wrocław. E-mail: durlik@pwr.wroc.pl