2004 issue 2

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Volume 13, issue 2

Review article

An overview of candidate genes in neurodevelopmental theory of schizophrenia – genes for trophic

MARIA SKIBIŃSKA1
1. Pracowni Genetyki Psychiatrycznej Katedry Psychiatrii Akademii Medycznej w Poznaniu
Postępy Psychiatrii i Neurologii, 2004, 13 (2), 125-133
Keywords: neurodevelopmental theory of schizophrenia, trophic factors, candidate genes, association studies

Abstract

Aims. Advances in the molecular genetics of schizophrenia are outlined with reference to the neurodevelopmental theory of schizophrenia. Two approaches are used in the research: the linkage analysis (whole genome screening) and the candidate gene method. The paper presents .findings of studies using the latter method which consists in selecting a priori the genes theoretically associated with the etiology of a given disorder.

Review. Research findings are presented concerning associative polymorphisms of the trophic factor genes (NT-3 – neurotrophin-3, BDNF – brain-derived neurotrophic factor, CNTF – ciliary neurotrophic factor, GDNF – glial-derived neurotrophic factor and NRG1 – neuregulin 1) that have been chosen on the grounds of the neurodevelopmental theory of schizophrenia.

Conclusions. The reported research findings indicate a significant role of brain-derived neurotrophic factor- and neuregulin l-encoding genes in the pathogenesis of schizophrenia.

Address for correspondence:
Mgr Maria Skibińska,
Pracownia Genetyki Psychiatrycznej Katedry Psychiatrii Akademii Medycznej,
ul. Szpitalna 27/33,
60-572 Poznań,
tel.: (61) 8491311, e-mail: mariaskibinska@yahoo.com