Aim. Alcoholics suffer from depressive and anxiety disorders three limes more often than a healthy population. Elevated levels of anxiety and depression are observed in the alcohol withdrawal syndrome. The aim of this study was to estimate the relationship between anxiety and depression levels in alcoholics (using psychometric scales: Zung's self-rating anxiety scale: SAS; Zung's self-rating depression scale: SDS) and the 5 candidate genes polymorphisms.
Method. 108 alcohol dependent patients, without other psychiatric illness than alcohol and/or nicotine dependence according to axis I of ICD-l0, were examined. Polymorphisms of DAT1, 5HTT, MAO A, COMT, DRD2 genes were tested.
Results. We found an association between some polymorphisms of tested genes and anxiety and depression levels estimated by the SAS and SDS scales.
Conclusions. The results of our study confirm the hypothesis about the biologically determined individual course of alcohol dependence.