2004 suplement 3

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Volume 13, suplement 3

Genetics

Association study between the DRD2, DATl, 5HTT, MAO A and COMT gene polymorphisms and the anxiety and depression levels in alcoholics

Justyna Pełka-Wysiecka1, Jerzy Samochowiec1, JOLANTA KUCHARSKA-MAZUR1, SZYMON SYREK1, MICHAŁ PARUS1, Anna Grzywacz1, JAN HORODNICKI1
1. Katedry i Kliniki Psychiatrii Pomorskiej Akademii Medycznej w Szczecinie
Postępy Psychiatrii i Neurologii, 2004, 13 suplement 3 (19), 35-46
Keywords: alcohol dependence, DAT1 gene, 5HTT gene, MAO A gene, COMT gene, anxiety, depression, SAS, SDS

Abstract

Aim. Alcoholics suffer from depressive and anxiety disorders three limes more often than a healthy population. Elevated levels of anxiety and depression are observed in the alcohol withdrawal syndrome. The aim of this study was to estimate the relationship between anxiety and depression levels in alcoholics (using psychometric scales: Zung's self-rating anxiety scale: SAS; Zung's self-rating depression scale: SDS) and the 5 candidate genes polymorphisms.

Method. 108 alcohol dependent patients, without other psychiatric illness than alcohol and/or nicotine dependence according to axis I of ICD-l0, were examined. Polymorphisms of DAT1, 5HTT, MAO A, COMT, DRD2 genes were tested.

Results. We found an association between some polymorphisms of tested genes and anxiety and depression levels estimated by the SAS and SDS scales.

Conclusions. The results of our study confirm the hypothesis about the biologically determined individual course of alcohol dependence.

Address for correspondence:
Dr Justyna Pełka-Wysiecka,
Katedra i Klinika Psychiatrii Pomorskiej Akademii Medycznej,
ul. Broniewskiego 26,
71-460 Szczecin,
e-ma.il: wysiecki@wp.pl