2004 suplement 3

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Volume 13, suplement 3

Genetics

The association between the dopamine transporter and COMT gene polymorphisms and the personality traits measured by the Temperamental and Character Inventory (TCl) and NEO-FFI in healthy volunteers

JOLANTA KUCHARSKA-MAZUR1, MICHAŁ PARUS1, SZYMON SYREK1, ANETA RYŻEWSKA1, Justyna Pełka-Wysiecka1, AGNIESZKA SAMOCHOWIEC2, JERZY SAMOCHOWIECI1
1. Katedry i Kliniki Psychiatrii Pomorskiej Akademii Medycznej w Szczecinie
2. Międzywydziałowego Studium Kształcenia Pedagogicznego Uniwersytetu Szczecińskiego
Postępy Psychiatrii i Neurologii, 2004, 13, suplement 3 (19), 25-33
Keywords: Temperamental and Character Inventory (TCI), NEO-FFI, dopamine transporter gene (DAT1), COMT gene, personality traits

Abstract

Aim. The association between the DAT1 and COMT gene polymorphisms and the temperament dimensions evaluated by the TCI and NEO-FFI inventories was studied.

Method. 181 healthy volunteers (without psychiatric disorders according to axis I of ICD-10), including 114 females (age 34,0 ± 12,4) and 67 males (age 35,1 ± 16,8), were recruited to represent a cross-section of the Szczecin's population in terms of sex, age, education, Caucasian race and Polish nationality.

Results. Statistically significant differences were obtained using the NEO-FFI inventory, i.e. the DAT1 genotype dependent Agreeableness and Conscientiousness and the COMT genotype dependent Neuroticism, Extraversion and Agreeableness. Probands carrying A9 allele of DAT1 gene polymorphism (males and the whole group) scored significantly lower in the Agreeableness scale (p < 0,05 and p ≤ 0,015 respectively) while males carrying A9 allele of DAT1 gene polymorphism scored significantly lower in the Conscientiousness scale (p < 0,05). Probands with G allele encoding the more active form COMT, scored significantly higher in Neuroticism (males: p = 0,001; the whole group: p < 0,05) and lower in Extraversion (p ≤ 0,015). Males carrying G allele scored significantly lower in Agreeableness (p < 0,05). Probands carrying A9 allele of DAT1 gene polymorphism scored significantly higher in the TCI's Novelty seeking scale (p < 0,05) and the NS4 subscale (p < 0,05). Probands carrying G allele of COMT gene polymorphism scored significantly higher in the NS2 subscale (p < 0,05). Conclusions. Our results do not support the hypothesis that there is a simple correlation between a single gene polymorphism and a personality trait measured by the TCI and NEO-FFI scales.

Address for correspondence:
Dr Jolanta Kucharska-Mazur,
Katedra i Klinika Psychiatrii Pomorskiej Akademii Medycznej,
ul, Broniewskiego 26,
71-460 Szczecin