2005 issue 2

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Volume 14, issue 2

Review article

Magnetic resonance spectroscopy in degenerative diseases of the central nervous system

Radosław Magierski1, Tomasz Sobów1, Iwona Kłoszewska1
1. Klinika Psychiatrii Wieku Podeszłego i Zaburzeń Psychotycznych Uniwersytetu Medycznego w Łodzi
Postępy Psychiatrii i Neurologii 2005; 14 (2): 155-163
Keywords: magnetic resonance spectroscopy, neurodegenerative diseases, dementia

Abstract

Objectives. The paper presents a review of research findings concerning changes in cerebral metabolites in the most common neurodegenerative syndromes: Alzheimer 's disease, dementia with Lewy bodies, frontotemporal dementia, Huntington 's disease, and Parkinson's disease.

Review. In contemporary medicine imaging techniques are of utmost importance among dynamically developing investigation methods. Magnetic resonance imaging is the leading investigation technique. One of MRI applications is magnetic resonance spectroscopy, available in several forms. The most frequently used proton emission spectroscopy enables to measure the levels of cerebral metabolites: N-acetyloasparginate, choline and its derivatives, myoinositol, creatine and creatine phosphate, as well as the glutamate-glutamine complex.

Address for correspondence:
Dr Radosław Magierski, Klinika Psychiatrii Wieku Podeszłego i Zaburzeń Psychotycznych Uniwersytetu Medycznego,
ul. Czechosłowacka 8/10, 92-216 Łódź, e-mail: rmagierski@o2.pl