2005 issue 3

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Volume 14, issue 3

Review article

Will statins be helpful in Alzheimer's disease?

Tomasz Pawełczyk1, Iwona Kłoszewska1
1. Kliniki Psychiatrii Wieku Podeszłego i Zaburzeń Psychotycznych Uniwersytetu Medycznego w Lodzi
Postępy Psychiatrii i Neurologii 2005; 14 (3): 195-209
Keywords: Alzheimer's disease, statins, cholesterol metabolism, ApoE, HDL lipoproteins

Abstract

Objective. Drawing upon the most recent literature the authors discuss the relations between cholesterol metabolism and dementia and the data suggesting the potential usefulness of statins in the prevention ofAlzheimer 's disease.

Review. The ageing of contemporary societies means that the health problems of old age will be more and more prevalent in the next few decades. It has been estimated that the number of cases of Alzheimer 's disease world-wide will increase fourfold by 2047. If the emergence of symptoms could be delayed by five years, the increase in morbidity rate would be reduced by one half. Drugs currently registered as treatments for Alzheimer 's mainly ensure symptomatic relief and symptom reduction.

Conclusions. Research efforts are currentlyfocused on the search for treatments which will prevent or delay symptom development. Several groups of compounds which may satisfy these expectations have been intensely studied in recent years. These include: non-steroid anti-inflammatory drugs, oestrogens, Vitamin E and lipid concentration reducers.

Address for correspondence:
Dr Tomasz Pawelczyk, Prof. Iwona Kłoszewska, Klinika Psychiatrii Wieku Podeszłego i Zaburzeń Psychotycznych Uniwersytetu Medycznego, ul. Czechosłowacka 8/10, 92-216 Łódź, tel. (42) 6757372, fax: (42) 6757729, e-mail: iklosz@csk.am.lodz.pl