Objective. The treatment of depression in Parkinson 's disease involves a risk of not only neurological symptoms aggravation, but also dangerous interactions between anti-Parkinsonian drugs and antidepressants. Nevertheless, it may improve the patient's wellbeing and functioning.
Case. A patient with a depressive episode in the course of advanced Parkinson 's disease, treated with mirtazapine.
Comment. Mirtazapine may be an effective and safe drug in the treatment of depression associated with Parkinson 's diseases in patients receiving concurrent treatment with Levodopa.