Objective. Assessment of the role of developmental CNS abnormalities in the onset and course of a schizophreniform psychotic disorder.
Case. A 21-year-old male patient treated since the age of 18 years, initially because of conduct disorders, and later for depressive and paranoid symptoms. In neuroimaging examination non-communicating hydrocephalus, cereballar cyst, and agenesis of corpus callosum were found.
Commentary. The case can be referred to the neurodevelopmental conception of schizophrenia. In non-progressing encephalopathy the psychotic process may develop for a long time symptom-free, with intellectual abilities unaffected. "Soft" neurological symptoms may be the first prodromal signs of the existing abnormalities.