2006 issue 2

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Volume 15, issue 2

Review article

Genetics of suicidal behavior

SYLWIA FUDALEJ1, Marcin Wojnar1, HALINA MATSUMOTO1, MARCIN FUDALEJ2
1. Katedry i Kliniki Psychiatrii Akademii Medycznej w Warszawie
2. Katedry i Zakładu Medycyny Sądowej Akademii Medycznej w Warszawie
Postępy Psychiatrii i Neurologii 2006; 15 (2): 105-83
Keywords: suicidal behavior, susceptibility, genetic polymorphisms

Abstract

Objectives. The paper presents an overview of population and molecular genetic studies dealing with etiology of suicidal behaviour

Background. Molecular studies are concerned first and foremost with the relationship between suicide and serotonin system genes. It is suggested that other genes, such as mono-amino transferase Type A gene, neurogenesis-related genes, and the cholecystokinine encoding gene, also have an important role. A predisposition to suicidal behaviour is hypothesized to be closely associated and co-hereditary with certain temperamental traits.

Conclusions. In the light of findings reported in the literature susceptibility to suicidal behaviour can be regarded as dependent on interaction of many factors, both of genetic and environmental nature. A tendency to attempt suicide can be genetically determined and hereditary, irrespective of any predisposition to various mental disorders.

Address for correspondence:
Dr Sylwia Fudalej, Katedra i Klinika Psychiatrii Akademii Medycznej, ul. Nowowiejska 27, 00-665 Warszawa, e-mail: sylwia-sn@wp.pl