2006 issue 2


Volume 15, issue 2

Clinical hints

Quetiapine - atypical neuroleptic with a moderate effect on carbohydrate and lipid metabolism

Tadeusz Pietras1
1. Klinika Pneumonologii i Alergologii Instytutu Medycyny Wewnętrznej Uniwersytetu Medycznego w Łodzi
Postępy Psychiatrii i Neurologii 2006; 15 (2): 121-125
Keywords: quetiapine, second generation neuroleptics, metabolic syndrome


Objectives. Quetiapine, a benzothiazepine derivative, is an atypical antipsychotic with confirmed efficacy in the treatment of schizophrenia and bipolar disorder.

Review. Atypical neuroleptics may be the cause of the metabolic syndrome including obesity, glucose intolerance, hyperinsulinism, and serum lipid disturbances. In contradistinction to olanzapine and clozapine, quetiapine aggravates the metabolic syndrome constituents to a small degree only. Both the clozapine and olanzapine treatment is associated with the highest riskfor the metabolic syndrome incidence and subsequent cardiac disease. Quetiapine generally shows low to moderate levels of mean weight gain, as well as of blood glucose, triglicerides, and cholesterol concentrations.

Conclusions. Quetiapine seems to be an effective neuroleptic in the treatment ofpsychotic disorders in patients at riskfor atherosclerosis and cardiac disease.

Address for correspondence:
Dr Tadeusz Pietras, Klinika Pneumonologii i Alergologii Instytutu Medycyny Wewnętrznej Uniwersytetu Medycznego, ul. Kopcińskiego 22, 91-123 Łódź, tel./fax: (42) 6782129, e-mail: cital200@wp.pl