2007 issue 2

Back

Volume 16, issue 2

Original article

Cardiovascular risk factors in patients with sporadic Alzheimer 's disease

Anita Małgorzata Geppert1, Elżbieta Maria Przedpelska-Ober1
1. Katedra i Klinika Neurologii Akademii Medycznej w Poznaniu
Postępy Psychiatrii i Neurologii 2007; 16 (2): 145-148
Keywords: cardiovascular risk factors, hypertension, cholesterol, Alzheimer's disease, early onset, late onset

Abstract

Objective. To estimate the prevalence of arterial hypertension (AH), hypercholesterolemia (HCh), type 2 diabetes (DM) and cardiac dysrhythmia (CD) in patients with the early- or late onset form of Sporadic Alzheimer 's Disease (AD).

Method. Participants in the study were 95 patients with the sporadic form of AD, (in that number 66 patients with late onset AD and 29 with early onset AD), as well as a control group of 73 patients. All AD patients were compared with the controls for the prevalence of AH, HCh, DM and CD. Moreover, the two subgroups of AD patients with early and late onset forms of the disease were compared.

Results. Both AH and HCh were found significantly more often in AD patients than in the controls. AH was the only factor differentiating between the late onset and early onset AD. No significant differences were found between the two AD subgroups as regards HCh, which turned out to be a stable disorder with the same prevalence in both these forms of AD.

Discussion. AD is a heterogeneous, primarily degenerative condition being the most frequent cause of dementia among adults. However, studies on the prevalence of risk factors for AD shed a new light on cardiovascular disorders showing their direct relationship to AD. Epidemiological research findings indicate that AH, HCh, DM, or atrial fibrillation may significantly influence the development of AD, affecting the risk of AD onset and accelerating the progression ofAD symptoms.

Conclusions. The results of our study suggest a particular role of hypercholesterolemia in the etiopathogenesis of AD.

Address for correspondence:
Dr Anita Geppert
Katedra i Klinika Neurologii Akademii Medycznej
ul. Przybyszewskiego 49, 60-355 Poznań
tel. (61) 8691530, 8691535
fax: (61) 8691697
e-mail: Anita_Geppert@poczta.onet.pl