2007 issue 3


Volume 16, issue 3

Review article

Antiphospholipid syndrome as the cause of cerebral stroke and of various neurological syndromes

Małgorzata Wiszniewska1, Anna Członkowska2
1. Oddział Neurologii Szpitala Specjalistycznego w Pile
2. II Klinika Neurologii Instytutu Psychiatrii i Neurologii w Warszawie
Postępy Psychiatrii i Neurologii 2007; 16 (3): 247-250
Keywords: antiphospholipid syndrome, cerebral stroke, headache, venous thrombosis


Objectives. Essential pathogenic and clinical characteristics of the antiphospholipid syndrome (APS) as the cause of various neurological syndrome are outlined.
Review. APS is a systemic autoimmune disease, in which the pivotal factor is the presence of antibodies directed against phospholipids commonly found in cell membranes of human organism. Typical symptoms of APS include: venous thrombotic-embolic disease, arterial thrombosis in the brain, moderate thrombocytopenia, and obstetric complications. Cerebral thrombosis may provide pathophysiological conditions underlying ischemic stroke in young adults. The most common neurological symptom of APS is headache. Since the syndrome can cause disorders both in the central and peripheral nervous systems, its neurological manifestations may be diverse. The treatment for APS is based on antiplatelet and anticoagulation oral drugs administered alone or together.
Conclusions. APS should always be taken into consideration when the patient presents with diverse unexplained symptoms, especially of thrombotic-embolic character In diagnosing the APS a good collaboration with hematologists is of utmost importance, since they can help not only with the hematological diagnosis, but also with treatment.

Address for correspondence:
Dr Małgorzata Wiszniewska
Oddział Neurologii Szpitala Specjalistycznego im St. Staszica
ul. Rydygiera 1, 64-920 Piła
e-mail: mpwisz@pi.onet.pl