Objective. The paper describes mechanism of action of new antiepileptic drugs.
Background. Epilepsy is a frequent disorder that affects about 1%% of the general population. At present seizures and epilepsy are assumed to result from an imbalance between excitatory and inhibitory systems in the CNS. A number of systems are involved in the maintenance of homeostasis: the GABA-ergic system, glutamatergic system, monoamines, neurotrophins, neuropeptides. Currently used antiepileptic drugs may cause many side effects and have no therapeutic effects in up to 25% of patients. That is why new antiepileptic drugs - more effective and with a better tolerance profile - are sought for.
Conclusions. Epilepsy treatment is based on pharmacological therapy. Antiepileptic drugs vary in their mechanism of action. Compo.u.n.ds blocking sodium and calcium channels and enhancing GABA-ergic neurotransmission seem to be the most promising candidates.