2008 issue 2

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Volume 17, issue 2

Review article

The role of Disrupted-In-Schizophrenia genes (DISC1 and DISC2) in schizophrenia - state of the art

Adam Wysokiński1, Wojciech Gruszczyński1
1. Klinika Psychiatrii Dorosłych II Katedry Chorób Układu Nerwowego Uniwersytetu Medycznego w Łodzi
Postępy Psychiatrii i Neurologii 2008; 17 (2): 149-155
Keywords: DISC1, DISC2, schizophrenia

Abstract

Objective. The role of DISC1 and DISC2 genes in the etiopathogenesis of schizophrenia has been examined in many recent studies.
Review. Although the results are ambiguous, they suggest a possible role of these genes in the development of schizophrenia and other mental disorders, e.g. bipolar affective disorder. The mechanisms through which the DISC1 and DISC2 genes operate are not entirely recognized but their proven participation in the process of neurogenesis and the occurrence of the mutations of DISC1 and DISC2 genes support the view that a disrupted neurodevelopment process plays an important role in the etiopathogenesis of schizophrenia.
Conclusions. Despite numerous evidences attesting to the association of these genes with the occurrence of schizophrenia, the clinical importance of these genes has not been established.

Address for correspondence:
Prof. Wojciech Gruszczyński
Klinika Psychiatrii Dorosłych Uniwersytetu Medycznego w Łodzi
Oddział XIB, Szpital im. J. Babińskiego ul. Aleksandrowska 159, 91-229 Łódź
tel. (042) 652-12-89
fax (042) 640-50-52
e-mail: klpsych@o2.pl