2008 issue 4


Volume 17, issue 4

Review article

Neurotrophins - the state-of-the-art knowledge

Adam Wysokiński1, Wojciech Gruszczyński1
1. Klinika Psychiatrii Dorosłych II Katedry Chorób Układu Nerwowego Uniwersytetu Medycznego w Łodzi
Postępy Psychiatrii i Neurologii 2008; 17 (4): 385-390
Keywords: neurotrophins, NGF, BDNF, NT-3, NT-4/5


Objective. In the article recent literature on neurotrophins is overviewed from the perspective of genetics, neurobiology, psychiatry and neurology, and major views on the subject, widely accepted at present, are discussed.
Review. Neurotrophins are a group of nerve growth factors participating in the processes of neuro- and synaptogenesis. Deficiencies of particular neurotrophins may lead to an abnormal development of the nervous system structures and to increased neuronal susceptibility to damage by physical and chemical factors, as well as by long-term stress exposure.
Conclusions. Neurotrophins play a crucial role in the etiopathogenesis of numerous mental and neurological disorders and therefore they remain one of the most important issues in experimental and clinical research.

Address for correspondence:
Dr Adam Wysokiński
Klinika Psychiatrii Dorosłych Uniwersytetu Medycznego w Łodzi
Oddział XIB, Szpital im. J. Babińskiego
ul. Aleksandrowska 159, 91-229 Łódź
tel. (042) 652-12-89
fax (042) 640-50-52
e-mail: adam.wysokinski@gmail.com