2010 issue 2


Volume 19, issue 2

Review article

Potential antidepressive mechanisms of the endocannabinoid system action

Piotr Wierzbiński1, Waldemar Kryszkowski1, Sławomir Szubert1, Antoni Florkowski1, Piotr Gałecki1
1. Klinika Psychiatrii Dorosłych Uniwersytetu Medycznego w Łodzi
Postępy Psychiatrii i Neurologii 2010; 19(2): 143–150
Keywords: endocannabinoids, neurotransmitters


Background. The endocannabinoid system (CB) is of special interest not only because of its involvement in the organism's energy regulation and digestive processes, but also due to its effect on the individual's psychological well-being. The aim of the paper was to describe and partially explain the mechanisms underpinning the endocannabinoid system action in the CNS.
Views. The endocannabinoid system is an intricate network of connections between neurons that affects serotonergic, noradrenergic and dopaminergic neurotransmission, as well as the hypothalamic-pituitary-adrenal axis. The system modifies GABA release. The pleiotropic effects of endocannabinoids instigate research into new substances that would have a selective effect on the endocannabinoid system.
Conclusions. Antidepressive and anxiolytic effects of endocannabinoids have been reported. A more thorough research on endocannabinoids and on new CB receptor ligands may lead to the development of drugs with a different mechanism of action that might be effective in the treatment of mood and anxiety disorders.

Address for correspondence:
lek. Piotr Wierzbiński
Klinika Psychiatrii Dorosłych Uniwersytetu Medycznego
Szpital im. J. Babińskiego,
Oddział XIB
ul. Aleksandowska 159, 91-229 Łódź