2010 issue 4

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Volume 19, issue 4

Case report

Persistent depression in the course of Cushing’s syndrome – a case report

Krzysztof Krysta1, Eliza Górniak1, Karolina Furczyk1
1. Klinika Psychiatrii i Psychoterapii, Śląski Uniwersytet Medyczny, Katowice
Postępy Psychiatrii i Neurologii 2010; 19(4): 305–307
Keywords: Cushing’s syndrome, depression, steroidogenesis inhibitors

Abstract

Objective. A case of persistent depression in the course of Cushing's syndrome is reported.
Case. A 55-year-old woman with a 10-year history of depression had been diagnosed with Cushing's syndrome after a year of antidepressant therapy. Surgery brought no improvement in her biochemical parameters. Antidepressant drugs turn out to be ineffective in the presence of persistent hypercortisolemia, and severity of the patient's depressive symptoms remains unchanged.
Commentary. Since a delayed diagnosis of Cushing's syndrome may prolong and complicate treatment, it is important to carefully exclude any somatic causes of depression in the diagnostic process. The emphasis of depression treatment should be on restoration of normocortisolemia, and e.g. steroidogenesis inhibitors may be helpful in this respect.

Address for correspondence:
Dr Krzysztof Krysta
Katedra i Kl. Psychiatrii i Psychoterapii Śl. UM
ul. Ziołowa 45/47 40-635 Katowice-Ochojec