2010 issue 4

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Volume 19, issue 4

Review article

The trigeminal nerve – structure and function

Ewa Bałkowiec-Iskra1
1. Katedra i Zakład Farmakologii Doświadczalnej i Klinicznej, Warszawski Uniwersytet Medyczny
Postępy Psychiatrii i Neurologii 2010; 19(4): 283–286
Keywords: brain-derived neurotrophic factor (BDNF), calcitonin gene-related peptide (CGRP), migraine, trigeminal nerve

Abstract

Objectives. To present the role of the trigeminal nerve in sensory information (including pain sensation) transmission from the meninges of the brain and spinal cord, the temporomandibular joint, and teeth.
Review. The molecular mechanisms of sensory transmission in the trigeminal system have not been fully identified so far. Apart from the neuronal activity also the calcitonin gene-related peptide (CGRP) and brain-derived neurotrophic factor (BDNF) are hypothesized to play a significant role in this respect.
Conclusion. Research into the role of the latter factors in modulation of the trigeminal nerve function may contribute to the development of new treatment paradigms for trigeminal neuralgia, among other conditions.

Address for correspondence:
Dr Ewa Bałkowiec-Iskra
Katedra i Zakład Farmakologii Doświadczalnej i Klinicznej, Warszawski Uniwersytet Medyczny
ul. Krakowskie Przedmieście 26/28, 00-927 Warszawa
tel./fax: 22-826-21-16
e-mail: ebalkowiec@wum.edu.pl