2012 issue 2

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Volume 21, issue 2

Original article

Metabolic syndrome and dementia

Hanna Wehr1, Małgorzata Bednarska-Makaruk1, Wanda Lipczyńska-Łojkowska2, Ałła Graban2, Anna Bochyńska2, Maria Rodo1, Danuta Ryglewicz2
1. Department of Genetics, Institute of Psychiatry and Neurology, Warsaw
2. First Department of Neurology, Institute of Psychiatry and Neurology, Warsaw
Postępy Psychiatrii i Neurologii 2012; 21(2): 117–122
Keywords: metabolic syndrome, dementia, insulin resistance

Abstract

Objectives. Co-occurrence of metabolic syndrome features and dementia was studied.
Methods. In 151 demented patients and 64 control individuals the presence of metabolic syndrome was diagnosed according to the modified Grundy et al. criteria (hypertension, obesity, high triglyceride and low high density lipopoprotein (HDL) cholesterol serum levels, as well as hyperglycemia). The serum insulin level was determined and the HOMA-IR index of insulin resistance was calculated. Polymorphic forms of a gene candidating for a role in the insulin signaling pathway – the glycogen-associated regulatory subunit 3 of protein phosphatase 1 (PP1R3), and of the apolipoprotein E gene - ε2, ε 3 and ε 4 alleles – which are well-known strong genetic risk factors for Alzheimer's disease - were identifi ed.
Results. Metabolic syndrome was found more often in the group with vascular dementia (VaD) than in the controls. In the former group a tendency for higher HOMA-IR index values was observed. The most frequent characteristic of glucose metabolism differing all the patients from the controls was an increased 2-hour postload glucose level, which is a feature of prediabetes. No differences between the patients and controls were found in the frequency of particular polymorphic forms of the PPP1R3 gene. Low HDL cholesterol levels and glucose intolerance – two important metabolic syndrome features - were signifi cantly more frequent only in the ε4 allele noncarriers, but not in the carriers of this allele.
Conclusions. Metabolic syndrome features were observed most often in patients with dementia of vascular origin. Frequency of these characteristics was higher only in noncarriers of the apolipoprotein E ε4 allele.

Address for correspondence:
Prof. Hanna Wehr
Zakład Genetyki, Instytut Psychiatrii i Neurologii
ul. Sobieskiego 9, 02‒957 Warszawa
tel. 22‒8589169
e-mail: wehr@ipin.edu.pl