Volume 4, issue 4
Diagnostyka obrazowa i neuropsychologiczna
The course of bipolar affective disorder related to CNS abnormalities investigated by MRI
STANISŁAW PUŻYŃSKI1, MARIA BERĘSEWICZ1, Iwona Koszewska1, ANDRZEJ BIDZIŃSKI3, WOJCIECH JERNAJCZYK4, EWA HABRA1, Renata Poniatowska2
1. I Kliniki Psychiatrycznej IPiN w Warszawie
2. Zakładu Neuroradiologii IPiN w Warszawie ³ Zakładu Biochemii IPiN w Warszawie
3. Zakładu Biochemii IPiN w Warszawie
4. Zakładu Elektroencefalografii i Elektromiografii IPiN w Warszawie
Postępy w Psychiatrii i Neurologii, 1995, 4, 381-390
Keywords: affective disorder – the course of, MRI, CT of the CNS, EEG, MAO, DBH index
Abstract
MRI examination of 40 patients with bipolar affective disorders (mean age 42,2±5,7 years) indicated in 57,5 of the cases atrophic changes in cerebral cortex, and in 32,5% an increased ventricular system volume, especially of the third ventricle. In 25% of patients scattered foci of hyperintensive signals were found. No significant relationship was found between the presence of the aforementioned structural abnormalities in the brain and severity of the illness course, cognitive impairments, and EEG changes in the waking period. In patients with severe course of the illness and atrophic cortical lesions a decrease in the MAO/DBH blood index level was observed.
Address for correspondence:
Prof Stanisław Pużyński,
II Klinika Psychiatryczna IPiN,
Al. Sobieskiego 1/9,
02-957 Warszawa